What does the human post-exposure prophylaxis (PEP) for rabies include for a previously unvaccinated person?

The correct answer includes immediate wound care, the administration of the rabies vaccine, and human rabies immune globulin (HRIG). This combination is critical for effectively managing rabies exposure in a previously unvaccinated individual.

Immediate wound care is fundamental because proper cleaning of the wound can significantly reduce the viral load and the risk of rabies infection. Following this, the rabies vaccine is administered to stimulate the immune system to produce antibodies against the rabies virus. The inclusion of HRIG is especially important for those who have not been vaccinated previously, as it provides immediate passive immunity. HRIG contains pre-formed antibodies that can help neutralize the virus until the vaccine has had time to induce an active immune response.

This three-pronged approach ensures comprehensive protection against rabies for someone who has been exposed to the virus but has not received prior vaccinations.